The band hails from Pittsburgh when in 2007 five musicians disillusioned from their previous experiences decided to join forces in something "insanely different" from what they have been doing until then and “give a nod to the music we listened to growing up in the 80's. One of the more important aspects of the new project was to not take ourselves too seriously and have fun with it”, tells the band’s guitar player Drew Donegan.

Since the release of the bands debut "Light Me Up" in 2009, Gene The Werewolf have been featured in various national and local publications including Spin Magazine, Pittsburgh Post Gazette, Tribune Review, Pittsburgh City Paper, and more. Gene was on SPIN magazine's Top 15 "Songs You Must Hear Now" in November 2009, and #2 on The Daily News "Best of 2009" list. The band has also enjoyed local and regional airplay along with frequent in-studio performances on 102.5 WDVE and 105.9 WXDX in Pittsburgh.

Late in 2010 Gene had the idea to cover a version of the 1978 local classic "Steelers Fight Song". Gene's version, named "Steelers Polka", went viral during the football season and received over 340,000 views on YouTube along with airplay from local and national radio.

In January of 2012, Gene's new single "I Only Wanna Rock N Roll" was added to full rotation to Pittsburgh's Clear Channel radio station 102.5 WDVE FM! It reached the "#1 most played single" on the station for over 5 weeks in a row, beating out the Foo Fighters and Nickelback.

In November 2012, Gene The Werewolf signed with European label Frontiers Records, home of iconic bands like Journey, Def Leppard, Night Ranger, Rick Springfield and more! Their international debut entitled "Rock N Roll Animal" was release in all of Europe on November 23 and in Japan on November 21.